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Results: We reveal that membrane disruption leads to enhanced passive diffusion of drug independent of drug efflux activity.We further explored that Van caused alterations in lipid as demonstrated by impaired lipid profile and enhanced lipase activity.His research areas mainly include the synthesis and electrochemical properties of electrode materials for lithium, sodium and magnesium ion batteries and characterizing the electrode materials using synchrotron x-ray based advanced techniques such as EXAFS and NEXAFS at Pohang Accelerator Laboratory (PAL), South Korea. Ji-Hoon Lee is currently working in Advanced Thin Films Department at Korea Institute of Materials Science (KIMS) as a senior researcher. Before joining the KIMS, he was a postdoctoral researcher at Korea Institute of Science and Technology (KIST). in inorganic chemistry at the University of Waterloo, Canada in 2011. degree in chemical engineering from Hanyang University, Republic of Korea in 2012. D., he worked on nanostructured anode materials for Li-ion batteries. in materials science in 2003 at Yonsei University, South Korea.His research focuses on the development of novel electrode materials based on metal-organic frameworks and their hybrid materials for electrochemical energy storage systems. Si Hyoung Oh is a principal researcher at the Korea Institute of Science and Technology (KIST) and an associate professor at Korea University of Science and Technology. He primarily works on the development of nanostructured materials for high-energy, low-cost, environmentally-benign energy storage systems. Hun-Gi Jung is a senior research scientist in Korea Institute of Science and Technology. His current research is focused mainly on electrode materials for Li-ion battery, Li-air battery, and all-solid-state battery as the next generation secondary batteries. Kyung Yoon Chung is head and principal researcher of the Center for Energy Convergence Research at Korea Institute of Science and Technology (KIST). Then he worked as a Research Associate at Chemistry Department of Brookhaven National Lab., USA. His research focuses on the electrode materials for the secondary batteries.and acetylene black is proposed as a high-performance anode material for sodium-ion batteries and their electrochemical performances, as well as related energy storage mechanism, are investigated.The nanocomposite electrode delivered a high reversible capacity of 563 m Ah g XRD and the results reveal the existence of a solid solution of two or more species during dis/charging.(2017) Elucidating the Mechanism of Vanillin Induced Mycobacterial Membrane Disruption: Implications of Lipid Alterations. DOI: 10.15226/sojmid/5/3/00174Background: Novel strategies to overcome Multidrug Resistance (MDR) in Tuberculosis (TB) still remain a concern.Usage of natural compounds nowadays to surmount the ever increasing burden of MDR-TB has shown promising results.
This is also supported by the effect of Van on colony morphology and cell sedimentation rate.
Commensurate with our findings, we also observed that Van leads to enhanced PI intake validating the hypothesis.
Furthermore, we also uncover additional phenotypes related to membrane disruption.
Emergence of MDR along with adverse side effect on human health due to prolong anti-TB drugs usage has nowadays prompted to identify novel and effective drugs from natural origin to overcome this fatal disease [3, 4].
Vanillin (Van), a natural phenolic compound, is extracted from seed pods of .