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live births (carrier incidence 0.0004, gene frequency 0.0002) and is more common than NF-2.
Neurofibromatosis also increases the risk of leukemia particularly in children; Children with NF-1 have 200 to 500 times the normal risk of developing leukemia compared to the general population.
Since the tumors grow where there are nerves, they can also grow in areas that are visible, causing considerable social suffering for those affected.
The tumors can also grow in places that can cause other medical issues that may require them to be removed for the patient’s safety.
Therefore, if only one parent has neurofibromatosis, his or her children have a 50% chance of developing the condition as well.
The severity in affected individuals can vary, this may be due to variable expressivity.